Mechanism of rat osteosarcoma cell apoptosis induced by a combination of lowintensity ultrasound and 5aminolevulinic acid in vitro. Apoptosis is used by multicellular organisms to remove cells that are not needed by the body. Apoptosis is an intrinsic cellsuicide programme which ensures proper development by maintaining tissue homeostasis and safeguarding the organism through the elimination of unwanted or virus. It is divided into three sections for convenient and easy reading. Among them, apoptosis is the most common and wellstudied type of pcd. Major players in apoptosis apoptosis initiating factoraif. Nearly 15 types of programmed cell death pcd have been identified to date. Introduction apoptosis, or programmed cell death, is a highly regulated process that allows a cell to selfdegrade in order for the body to eliminate unwanted or dysfunctional cells. Causative factors such as alcohol, viruses, toxic bile acids, fatty acids, drugs, and immune response, can induce apoptotic cell death via. A detailed description of programmed cell death mechanism also called apoptosis.
The molecular mechanisms of organotininduced apoptosis, which involve a series of biochemical regulators and molecular interactions, have been extensively studied in. Mechanism intrinsic mitochondria contains proteins like apoptosis inducing factor aif, smac diablo and cytochrome c that. It is a pattern of cell death in which single or cluster of cells appear on sections stained with h. Apoptosis is a biological mechanism which is one type of programmed cell death. The knowledge of apoptotic mechanisms is essential in many biologic aspects related to both normal and neoplastic cells. Cell death by apoptosis is a very desirable way to eliminate unwanted cells. The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. Ppt mechanisms of apoptosis and cytotoxicity powerpoint. Biochemical events lead to characteristic cell changes morphology and death. The role of apoptosis in cancer development and treatment. There is also a growing body of evidence indicating that nitric oxide is able to induce apoptosis by helping to.
Morphological changes in apoptosis hengartner, 2000 9 10. The first section which comprises two chapters is an. During the embryonic development, the worm produces exactly 1090 cells. This book looks at the latest research studies on apoptosis in medicine. Apoptosis is a prominent feature of liver diseases. Pdf mechanism of rat osteosarcoma cell apoptosis induced. There are 3 major pathways by which apoptosis takes place intrinsic pathway mitochondrial pathway extrinsic pathway t cell mediated. The term apoptosis was coined by john kerr, andrew wyllie and a.
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